Our acetylomics data showed that the proteins in the lung tissue of COPD mice were mainly hyperacetylated and enriched in the pathways related to energy metabolism, mitochondrial function, ECM, and cell proliferation, and the differential acetylation sites were mainly distributed in the protein domains, such as laminin, EGF, and acyl-CoA. This evidence concerns the gene EGF and chronic obstructive pulmonary disease.