KRAS and gallbladder cancer: Experiments have demonstrated that there is both the possibilityof a direct effect of the NS3 and E1 proteins on theactivity of c-Jun/AP-1 (de Chassey et al., 2008), and the lattercan affect the expression of the WIF1 gene through interactionwith the DNMT1 methyltransferase (DNA methyltransferase1), suppressing WIF1 in gallbladder cancer cells (Lin etal., 2018).