Based on traditional histological classification, molecular parameters are closely related to the diagnosis, treatment, and prognosis of glioma, including 1p/19q codeletion status; isocitrate dehydrogenase 1(IDH1) mutation, H3G34 mutation, and H3K27 mutation are included in the 2021 World Health Organization Classification of Tumors of the Central Nervous System [6]. The gene discussed is IDH1; the disease is glioma.