Using the cluster heat map, UALAN website, GEPIA, and GEPIA2 online software and the Kaplan–Meier plotter online tool to analyze and verify the correlations of expression and survival rate of the four selected key core genes, it was found that the expression levels of these four genes in tumor tissues with P53 mutation were significantly higher than those in tumor tissues without P53 mutation and normal tissues. Here, TP53 is linked to neoplasm.