In the research result section, the differential expression of CDK1, CCNB1, and CCNB2 genes reported in the literature is consistent with this article, but we found four core genes in 969 lung tumor tissues and 685 normal lung tissues through in-depth analysis and verification, elaborated the expression of these four genes in lung squamous cell carcinoma and lung adenocarcinoma and their relationship with the prognosis of 1925 lung cancer patients, and analyzed their correlation with P53 mutation in lung cancer. The gene discussed is TP53; the disease is squamous cell lung carcinoma.