TP53 and diabetes mellitus: After KEGG pathway enrichment analysis, the results showed that (P < 0.05, Supplementary documents Table S3) the upregulated DEGs were mainly concentrated in the cell cycle, P53 signaling pathway, cell cycle yeast, cell aging, progesterone-mediated oocyte maturation, and yeast meiosis pathways; downregulated DEGs were mainly concentrated in the AGE-RAGE signaling pathway, PPAR signaling pathway, fluid shear stress and atherosclerosis, complement and coagulation pathways in malaria, vascular smooth muscle contraction, and diabetes complications.