After KEGG pathway enrichment analysis, the results showed that (P < 0.05, Supplementary documents Table S3) the upregulated DEGs were mainly concentrated in the cell cycle, P53 signaling pathway, cell cycle yeast, cell aging, progesterone-mediated oocyte maturation, and yeast meiosis pathways; downregulated DEGs were mainly concentrated in the AGE-RAGE signaling pathway, PPAR signaling pathway, fluid shear stress and atherosclerosis, complement and coagulation pathways in malaria, vascular smooth muscle contraction, and diabetes complications. This evidence concerns the gene RENBP and malaria.