CCNB1 and lung cancer: At the same time, according to the analysis results of the above four pathways, the expression levels of CHEK1, CCNB1, CCNB2, and CDK1 in lung cancer tissues were significantly higher than those in normal tissues, and the expression of these four genes is negatively correlated with the prognosis and survival rate of lung cancer patients, and are valuable prognostic predictors.