Their research demonstrated that the BRAF V600E mutation in LCH may be significantly correlated with the regulation of programmed cell death 1 ligand 1 (PDL1) expression and forkhead box protein 3 (FOXP3)(+) regulatory T-cell infiltration and closely related to the long-term survival of patients [28]. This evidence concerns the gene BRAF and Langerhans cell histiocytosis.