BRAF and Langerhans cell histiocytosis: Moreover, Bigenwald et al. also reported that enforced expression of the BRAF V600E mutation in early mouse and human multipotent hematopoietic progenitor cells induced a senescence program that led to hematopoietic progenitor cell growth arrest, apoptosis resistance, and senescence-associated secretory phenotype, which contribute to the formation of LCH lesions [6].