Secondly, licochalcone A not only directly inhibited the activation of the TNF-α/NF-κB pathway but also exhibited strong potential in the inhibition of angiotensin converting enzyme (ACE) in hypertension, heart failures and myocardial infarction (Funakoshi-Tago et al., 2009; Ke et al., 2017). This evidence concerns the gene NFKB1 and heart failure.