In the tissues of colon cancer patients, patients with more activated DC infiltration had a better prognosis and longer disease-free survival, which was also related to the colocalization of IRF7 on DCs and CD8+ T cells expressing granzyme B in different tumor regions contributing to the antitumor effect (Kiessler et al., 2021). The gene discussed is GZMB; the disease is colonic neoplasm.