NRGN and atherosclerosis: A pathway-target network was constructed for the top 18 KEGG pathways that were mainly enriched for the targets (Figure 5A) (Table 3), and the main pathways were found to be enriched for Lipid and atherosclerosis (hsa05417), cAMP signaling pathway (hsa04024), VEGF signaling pathway (hsa04370), inflammatory mediator regulation of TRP channels (hsa04750), exhibiting the multi-target and multi-pathway characteristics of NG-R1 against septic myocardial injury.