EDN1 and endothelial dysfunction: Increased EDCFs, including endothelin (ET)-1, EC-derived adenosine diphosphate, angiotensin II, 5-hydroxytryptamine (5-HT), 8-iso-prostaglandin F2α (PGF2α), and thromboxane A2 (TXA2), which can also antagonize the protective and vasodilative effects of EDRFs, ultimately lead to endothelial dysfunction.