CRYAB gene was significantly upregulated in the advanced pathological stage of COAD, cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), STAD, ovarian serous cystadenocarcinoma (OV), and BLCA (P < 0.05) (Figure 2D). The gene discussed is CRYAB; the disease is colon adenocarcinoma.