CRYAB gene was significantly upregulated in the advanced pathological stage of COAD, cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), STAD, ovarian serous cystadenocarcinoma (OV), and BLCA (P < 0.05) (Figure 2D). This evidence concerns the gene CRYAB and bladder transitional cell carcinoma.