The results indicated that CRYAB-related genes enriched in “Alzheimer”s disease”, “Human cytomegalovirus infection”, “Hepatitis C”, “Apoptosis”, “Signaling pathways regulating pluripotency of stem cells”, “EGFR tyrosine kinase inhibitor resistance”, “Apoptosis—multiple species”, and “p53 signaling pathway”. This evidence concerns the gene TP53 and early-onset autosomal dominant Alzheimer disease.