In recent years, several studies have reported that bladder cancer is associated with the expression of certain genes and proteins, which can be used to determine metastasis, prognosis and treatment of bladder cancer (23), Currently, Smith, et al. has already established a 20 genetic models for identifying bladder cancer patients with high risk of lymph node metastasis (24), in addition, Karyopherin-a2 (KPNA2) interaction with Chromobox 8 (CBX8) has been suggested as an indicator that patients are at high risk of metastasis (25). Here, KPNA2 is linked to metastatic malignant neoplasm in the lymph nodes.