CD4 and diffuse large B-cell lymphoma: The infiltration levels of naive B cells, memory B cells, resting CD4+ memory T cells, regulatory T cells (Tregs), follicular helper T cells, and activated natural killer (NK) cells were higher in subtype A, while CD8+ T cells, activated CD4+ memory T cells, gamma delta T cells, M1 macrophages, plasma cells had significantly lower infiltration in subtype A compared to those in subtype B. In addition, we also carried out the ssGSEA algorithm in TCGA-DLBCL to further validate the differences in TME cell infiltration between the cuproptosis subtypes (Figure 4A).