In the testing set, the AUCs of the ROC curves for predicting the 2- and 4-year survival of PC patients were 0.75 and 0.776, respectively (Figure 4C), We observed that individuals with a low RS had poorer clinical outcomes than those with a high RS for HSD11B1 (HR=0.44, 95%CI=0.13-1.42, P=0.169) and NDRG1 (HR=0.39, 95%CI=0.16-0.94, P=0.035). This evidence concerns the gene NDRG1 and pachyonychia congenita.