In terms of molecular subtypes of CRC, CRCs can be classified into three distinct molecular signatures based on integrated DNA methylation and mutation profiling, including CpG island methylator phenotype (CIMP) 1, characterized by MSI (80%) and BRAF mutations (53%) and rare KRAS and TP53 mutations (17, 18). The gene discussed is BRAF; the disease is colorectal carcinoma.