In this regard, single-cell RNA-sequencing (scRNAseq) data from breast cancer patients showed that tumor cells display a gene signature associated with higher glucose consumption compared to normal epithelial cells (25), and glucose consumption by pancreatic ductal adenocarcinoma (PDAC) cell lines has been reported to impair proliferation of CD8+ T cells (26). This evidence concerns the gene CD8A and breast carcinoma.