Past studies have shown that the PI3K-Akt signaling pathway was involved in the invasion and metastasis of a variety of cancers, including hepatocellular carcinoma (73), gastric cancer (74, 75), lung adenocarcinoma (76), colorectal cancer (77), and renal cell carcinoma (78). Here, AKT1 is linked to hereditary clear cell renal cell carcinoma.