As shown in Figure 11B, we analyzed the somatic landscape of the TCGA-STAD cohort and demonstrated the top 10 genes with the highest mutation frequency in the tumor samples by waterfall plots, including TTN, TP53, MUC16, LRP1B, SYNE1, CSMD3, ARID1A, FLG, PCLO, and FAT4 (Figure 11B). This evidence concerns the gene FLG and neoplasm.