Because BMSC-derived adipocytes have been shown to regulate dexamethasone resistance in myeloma (11, 26), we also investigated the expression of two genes involved in glucocorticoid receptor trafficking in MM cells previously found to be upregulated in MM cells by BMAds (TSC22D3 and FKBP5); no differences in response to pBMAd co-culture relative to MM cells alone were found (Supplementary Figure 6B), suggesting differences between pBMAds and BMSC-derived BMAds in their relationship with myeloma cells, which warrants further study. Here, TSC22D3 is linked to plasma cell myeloma.