In cervical carcinoma (21), breast cancer (19), and lung cancer (23) cells, STIP1 knockdown induced apoptosis without any stress condition, which differs from our results with OSCC cells and suggests differential regulation of apoptotic process by STIP1, which can be related to the observed dysregulation of the autocrine effects of cytokines and/or growth factors. This evidence concerns the gene STIP1 and breast cancer.