Mechanistically, it was showed that STIP1 may activate distinct signaling pathways in the context of the specific cell type and cancer biology, including PI3K/Akt (14), Wnt/β-catenin (20, 21), ERK1/2 (22), JAK2/STAT3 (16, 23) and ALK2-SMAD1/5 (11). Here, STIP1 is linked to cancer.