Regarding to the orthotopic CRC, the expression levels of apoB were higher in the liver-metastatic CRC than the CRC patients who did not present metastasis (22 and 0 out of 34 vs. 16 and 1 out of 89 for medium and strong expression, respectively, P<0.001, Figure 5B). This evidence concerns the gene APOB and colorectal carcinoma.