This is consistent with our results (BIRC5 and HK2 are downregulated genes), so we speculate that the spontaneous regression of stage MS NB is likely to be related to the autophagy and apoptosis processes related to BIRC5 and HK2 because when the expression levels of BIRC5 and HK2 are low, the inhibition of apoptosis and autophagy by other factors will be relieved. This evidence concerns the gene HK2 and neuroblastoma.