Also, the IGF-1R protein level of expression differed significantly between patients with bone tumors and healthy controls (Cut off > 10.13, AUC=0.94, P<0.0001), patients with a malignant tumor and healthy controls (Cut off > 15.03, AUC=1, P<0.0001), patients with benign tumor and healthy controls (Cut off > 8.93, AUC=0.83, P<0.0001) and patients with bone malignant and benign tumor (Cut off > 19.98, AUC=1, P<0.0001). This evidence concerns the gene IGF1R and cancer.