Examining the relationship between levels of IGF-1, IGFBP-1, IGFBP-3, and/also IGF-1R gene and protein expression level with patient age, tumor size, tumor grade, metastasis, tumor recurrence, and malignancy showed the positive correlation between the mentioned tumor features with IGF-1, IGFBP-1, IGFBP-3 and IGF-1R gene and protein expression level. This evidence concerns the gene IGFBP1 and neoplasm.