Considering that IGF-1 secretion occures in an age-dependent manner and its level is increased during puberty (43), it is possible that an unequal distribution of patients in terms of age in this study may lead to the lack of appropriate conclusions in this field and investigating the relationship between the age of patients with bone tumors and the level of IGF axis production should be perused in future studies. The gene discussed is IGF1; the disease is bone neoplasm.