The IGFBP-1 level was increased a significantly in patients with osteosarcoma (43.70 ± 2.23) (P=0.0001) and Ewing sarcoma (38.82 ± 1.29) (P=0.002) compared to the healthy controls (32.48 ± 1.55); while no significant difference was detected between osteosarcoma and Ewing sarcoma. This evidence concerns the gene IGFBP1 and osteosarcoma.