The exposure of sevoflurane could restore the level of miR-29a and inhibit tumor progression by lowering the expression of long non-coding RNA KCNQ1 opposite strand/antisense transcript 1 (lncRNA KCNQ1OT1) (26), which led to the reduction of DNA methyltransferase 3 alpha (Dnmt3a) (25) and chromebox protein homolog 3 (CBX3) (26) in HCC cell lines. The gene discussed is DNMT3A; the disease is neoplasm.