For example, propofol could inhibit HCC progression by increasing the level of miR-4458 via modulating HOMEOBOX A11 antisense RNA (HOXA11-AS)/miR-4458 (39) axis as well as reducing HCC growth and metastasis through lncRNA H19/miR-520a-3p/LIM domain kinase 1 (LIMK1) axis (40). The gene discussed is IGKV3D-20; the disease is hepatocellular carcinoma.