By exploring TCGA and SpliceSeq databases, researchers revealed the aberrant alternative splicing events of DAZAP1, RBM4, ESRP1, and QKI and splicing factors of ESRP1 and RBM5, which contribute to the development of pancreatic ductal adenocarcinoma (PDAC) (15, 16). This evidence concerns the gene ESRP1 and pancreatic ductal adenocarcinoma.