TRIM63 and infection: Using THP1 cells bearing a SEAP reporter whose expression was driven by interferon response factor (IRF) activity (THP1-Blue ISG cells), we confirmed that the deletion of a subset of these immunomodulators to generate attenuated OncoVACV yields a virus whose infection induces higher levels of IFN signaling activity than its parental Copenhagen strain (Supplementary Figure 6) (25).