Absent or weak modulations of ERCC1 was detected after exposure to 1.8 Gy of radiotherapy in cell lines, which might be associated with the inhibition of the regulatory axis p53-EGFR-ERCC1. Increased expressions of ERCC1 (5/10 patients; P=0.0294) was found in malignant tissues after radiotherapy with the same radiation dose. This study showed that upregulation of ERCC1 may be part of a radioresistance mechanism in cervical cancer. Here, EGFR is linked to cervical cancer.