GNRH1 and thymus atrophy: GnRH agonist prevents the apoptosis of lymphocytes and attenuates the lipopolysaccharide (LPS) induced thymic atrophy in mice (34).GnRH also increases the percentages of CD4+ T lymphocytes in immunocompromised rats, and may participate in regulating the proliferation, activation, or functions of T helper cells (35).