A 64-year-old Chinese male was diagnosed as DLBCL (non-GCB, stage IV) in June 2015, based on the IHC analysis of cervical lymph node biopsy showing CD19 (+), CD20 (+), CD3 (-), CD5 (-), CD10 (-), CD45 (+), BCL2 (+), BCL6 (-), MUM1 (+), MYC (-) and Ki-67 (+, 80%). This evidence concerns the gene IRF4 and diffuse large B-cell lymphoma.