Although we and others have observed transient increases in NELF IgA levels from vaccinees with prior SARS-CoV-2 infection (22, 41, 43), intramuscular vaccination with adenovirus- and mRNA-based COVID-19 vaccines does not appear to induce anamnestic NELF IgA responses in SARS-CoV-2-seronegative vaccinees despite eliciting IgA responses in serum (43–45). The gene discussed is CD79A; the disease is COVID-19.