Current studies on the involvement of histone methylase and demethylase in anti-tumor immunity mainly includes (1): regulation of tumor immunogenic antigen expression; (2) their influence on the activation of immune-related pathways; (3) regulation of expression of chemokines/cytokines and induced immune-related factors; (4) regulation of immune cells, including immune cell activation, immune cell depletion and functional remodeling, and immune memory. The gene discussed is MBD2; the disease is neoplasm.