CD274 and colorectal cancer: KDM4C is also involved in the regulation of PD-L1 expression, and the main mechanism is the transcriptional activation of the Notch gene and PD-L1 through ARID3B recruitment to regulate chromatin structure, whereas KDM4D promotes PD-L1 expression through the SP-1/STAT3/IRF1 signaling pathway, assisting the immune escape of in colorectal cancer (114, 115).