TLSs were first reported in solid tumors in a retrospective study of 74 patients with early-stage NSCLC, called Ti-BALT, and consisted of an organized distribution of mature DC/T-cell populations and B-cell follicles; the high density of mature DC-LAMP+ (CD208+) DCs, a hallmark of Ti-BALT, was associated with favorable clinical outcomes (47). Here, LAMP3 is linked to non-small cell lung carcinoma.