CCL21 and neoplasm: Likewise, the expression of LIGHT (also known as tumor necrosis factor ligand superfamily member 14, TNFSF14) in fibrosarcoma cell lines upregulates CCL21 and MAdCAM1 on the tumor vasculature and favors the recruitment of massive numbers of naïve CD8+ T cells, followed by full activation in situ to promote rejection of established, highly progressive tumors (99).