Meanwhile, the antiviral response of Lc-TRAF3 mediated against SVCV infection in EPC cells was impaired when Lc-SARM co-expressed with Lc-TRAF3, and the transcriptional levels of IFN1 and IRF3 were also significantly down-regulated in Lc-SARM and Lc-TRAF3 co-expressed LYCMS cells compared with the overexpression of Lc-TRAF3 alone. The gene discussed is IRF3; the disease is infection.