IRF3 and infection: The results showed that the EPC cells only overexpression of Lc-TRIF, Lc-TRAF3, Lc-IRF3, or Lc-IRF7 could significantly decreased the mRNA expression levels of compared to the control cells transfected with the empty pcDNA3.1 vector at 24 h post-infection, whereas the only overexpression of Lc-SARM showed no obvious difference to that of the control cells on the expression of SVCV-G and SVCV-M (Figures 11A, B).