The authors identified increased pre-treatment anti-guanine nucleotide-binding protein G subunit alpha (anti-GNAL) which was associated with hypophysitis (OR = 2.66; 95% CI 1,14-7.29 p = 0.02, AUC = 0.79), and anti-CD74 levels with pneumonitis (OR = 1.25; 95% CI 1.03-1.52 p = 0.03, AUC = 0.76). This evidence concerns the gene GNAL and hypophysitis.