Several ICI clinical trials have outlined a profile of toxicities involving various organ systems, including dermatological, such as maculopapular rash and pruritus (4), pneumonitis in the lungs, gastrointestinal including diarrhea and colitis (5) and hepatic toxicity, which presents with increases in circulatory liver enzymes such as aspartate (AST) and alanine transaminases (ALT) (5). The gene discussed is GPT; the disease is colitis.