S53 on ORF9b was identified as an infection-driven phosphorylation site where serine formed a hydrogen bond with glutamic acid at E477 on TOM70, revealing the regulatory mechanism of ORF9b-TOM70 interaction: the binding of the phosphorylated ORF9b of variant to TOM70 was significantly reduced, and the binding of heat shock protein 90 (Hsp90) to TOM70 was not competitively inhibited (33). The gene discussed is TOMM70; the disease is infection.