That, in turn, induces the activation of the PI3K/Akt/eNOS pathway, restoring endothelial function (82), which is important because, in CCC, endothelial dysfunction contributes to the pathogenesis of cardiomyopathy by increasing leukocyte recruitment and inducing local vasoconstriction, with the consequent focal ischemia commonly observed in this pathology (83). The gene discussed is AKT1; the disease is endothelial dysfunction.