To determine the contribution of adrenal SR-BI to sepsis, Huby’s group used hypo-SF1CreSR-BIfl/fl mice (29). A limitation of this model is hypomorphism, as shown by that the floxed mice displace a 90% decrease in SR-BI expression globally including adrenals (30); we previously generated adrenal SR-BI-/- mice by adrenal transplantation (31). A limitation of this model is the cutoff of communication between preganglionic sympathetic neurons and chromaffin cells in the adrenal medulla, which blocks catecholamine production. Here, SCARB1 is linked to Sepsis.