AKT1 and infection: This is consistent with the results obtained in our proteomic analysis, and thus, the in vitro cellular assays also validated that the PI3K-Akt signaling pathway and MAPK signaling pathway are central pathways in the infection of mouse colon tissues by C. jejuni and that Akkermansia and its metabolites butyric acid and deoxycholic acid also resist C. jejuni by intervening in the PI3K-Akt signaling pathway and MAPK signaling pathway.