In this study, the authors explored the short-term proinflammatory potential of Akkermansia in IL-10-/- mice and found that Akkermansia administration did not alter pathogenic E. coli NC101 infection in germ-free IL-10-/- mice; similarly, after 3 weeks of Akkermansia gavage, there was no indication that it promoted simplified human intestinal microbiota (SIHUMI) colonization and exacerbated inflammation in IL-10-/- mice. The gene discussed is IL10; the disease is infection.