Extensive laboratory data gathered from experimental SIVsab infection in Caribbean AGMs demonstrates that a benign course of the infection characterized by high peak viremia of 107-108 copies/ml 8-10 days postinfection (dpi) that drops to set point values of 2x105 copies/ml by 28 dpi, a transient CD4+ T-cell decrease in the blood and lymph nodes, and a lack of systemic T-cell activation (22). The gene discussed is CD4; the disease is infection.