Additionally, the study found that tumors with a high hub-gene score, low TF and miRNA scores tended to have high tumor purity, low immune and stromal scores, low infiltration levels of activated CD4 and CD8 T cells, central memory CD4 T cell, effector memory CD8 T cell, neutrophil, activated B cell and eosinophil, as well as decreased expressions of exhausted immune markers including CD48, LAG3, CTLA4 and TIGIT. Here, CD4 is linked to neoplasm.