Gamma interferon effectively activates macrophages and directs B-cell immunoglobulin synthesis, type conversion, and secretion; gamma interferon plays an important role in several inflammatory disease processes such as autoimmunity and atherosclerosis.OSP, CMP, CVP, MEP, IOP, TAP, FVP, POP, VVP, ABP, HEP, and PEP all promote IFN-γ production by macrophages extremely significantly in a significant dose-dependent manner, reaching a minimum of 25.48% and a maximum of 106.06% of the positive control. The gene discussed is IFNG; the disease is atherosclerosis.