(33) analyzed 823 cancer cell lines derived from 23 different tissue types for the TERT promoter methylation, and they observed a highly consistent TERT promoter methylation pattern across cell lines: hypermethylated upstream of the transcription start site (UTSS) region while hypomethylated (transcription start site) TSS or proximal promoter region (Figure 3A). The gene discussed is TERT; the disease is cancer.