We first found that the cotreatment with the MEK inhibitor trametinib and natural products, dietary monoterpene perillyl alcohol (POH) or the sesame lignan sesaminol (Fig. 1A) suppressed both cell growth (Fig. 1B and C) and colony formation (Fig. 1D and E) in HCT116 human colorectal cancer cells with RAS mutation. The gene discussed is MAP2K7; the disease is colorectal cancer.