TP53 and colorectal cancer: For a more comprehensive analysis, we used the Cancer Dependency Map (DepMap; https://depmap.org/portal/) (22) and observed a significant inverse correlation between the protein expression of RPS5 and p53 in a panel of 29 colorectal cancer cell lines (Pearson correlation = −0.4293, P < 0.05) and 74 lung cancer cell lines (Pearson correlation = −0.3288, P < 0.01; Fig. 4E).