So, the reported in the present study the three-gene diagnostic signature CYP2E1, AKR1C3, AFP as well as the four-gene prognostic signature including SOCS2, MAGEA6, RDH16, and RTN3 are supported by the potential biological role of the respective proteins in the pathogenesis of HCC. This evidence concerns the gene CYP2E1 and hepatocellular carcinoma.