LncRNA PVT1 promotes cancer initiation and progression by acting as a competing endogenous RNA (ceRNA), activating STAT3 signaling or KAT2A acetyltransferase, or interacting with myelocytomatosis oncogene (MYC) (Zhao J. et al., 2018; Jin et al., 2019; Sun et al., 2019). Here, STAT3 is linked to cancer.