Advances in canine obesity is still in its early stage; however, a decrease of inflammatory markers, such as CRP and Hp, has been observed after weight loss in previous studies, suggesting that also dogs may suffer from a compelling association between low-grade inflammatory state and obesity (German et al., 2009; Ricci et al., 2011; Wakshlag et al., 2011). Here, HP is linked to obesity due to melanocortin 4 receptor deficiency.