Bidirectional crosstalk between mitochondria and NOX, markedly affects redox responses to angiotensin II, the ligand of ACE2 that is upregulated in viral infections (Doughan et al., 2008; Wosniak et al., 2009; Lee et al., 2013; Daiber et al., 2017). The gene discussed is AGT; the disease is viral infectious disease.