GRN and infection: To further investigate the mechanism underlying the role of PGRN in influenza virus infection, the global cellular protein expression profiles of lung tissues infected with PR8 virus at 0 day post-infection (dpi) and 3 dpi was analyzed by the multiplexed tandem mass tag (TMT) method which has been widely applied for investigating the potent antiviral agents and different signaling pathways (Yang et al., 2019).