CRH and Anxiety: Consistent with a critical role for BNST 5-HT2C activation in emotion-related responding, Marcinkiewcz et al. (2016) demonstrated that serotonin release from dorsal raphe afferents in the BNST acts on 5-HT2C receptors to excite a subpopulation of corticotropin-releasing factor (CRF) neurons to promote anxiety-like behavior, and also showed that 5-HT2C receptors in the ventral BNST may mediate anxiety-related behaviors during alcohol withdrawal (Marcinkiewcz et al., 2016).