While it is tempting to argue that changes in BNST 5-HT2C function may also underlie the antidepressant actions of exercise, the role of BNST activity in depression behaviors is less clear and to our knowledge BNST 5-HT2C manipulations have only been made in the context of fear- and/or anxiety-related behaviors (Levita et al., 2004; Fox et al., 2008; Guo et al., 2009; Katzman, 2009; Marcinkiewcz et al., 2015). The gene discussed is HTR2C; the disease is major depressive disorder.