The ANXA2 expression positively correlated with TMB in eight types of cancer (all r > 0): COAD (p < .001), LGG (p < .001), PAAD (p < .001), SARC (p < .001), SKCM (p = .002), STAD (p < .001), THYM (p = .0017) and UCEC (p < .001). This evidence concerns the gene ANXA2 and cancer.