Based on the TCGA database, the expression of ANXA2 in cervical squamous cell carcinoma (CESC), CHOL, COAD, esophageal carcinoma (ESCA), GBM, head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), LIHC, STAD, thyroid carcinoma (THCA) and uterine corpus endometrial carcinoma (UCEC) was higher compared with corresponding normal tissues. The gene discussed is ANXA2; the disease is carcinoma of esophagus.