Worgall et al. (2008) administered a total average dose of 2.5 × 1012 particle units of an AAV2 vector encoding human CLN2 cDNA (AAV2CUh-CLN2) into 12 locations in the CNS in 10 children with LINCL. Here, TPP1 is linked to late infantile neuronal ceroid lipofuscinosis.