TP53 and cancer: Numerous experiments have confirmed that mutated TP53 will acquire malignant biological functions in tumorigenesis, including promoting tumor cell survival, proliferation, migration, and invasion, enhancing chemoresistance, and promoting cancer metabolism (Dittmer et al., 1993; Brosh and Rotter, 2009; Muller and Vousden, 2013; Zhang et al., 2013) (23263379, 19693097, 8099841, 24343302).